When mismatch repair met translesion synthesis
نویسندگان
چکیده
منابع مشابه
Mismatch repair provides a security patch for translesion synthesis
Tsaalbi-Shtylik et al. reveal that DNA mismatch repair (MMR) proteins suppress UV-induced mutagenesis by removing nucleotides introduced by error-prone DNA polymerases. The MMR pathway is best known for its role in correcting the rare mistakes of replicative DNA polymerases. However, the MMR proteins Msh2 and Msh6 have also been implicated in preventing the introduction of DNA mutations followi...
متن کاملPost-translesion synthesis repair
Unrepaired DNA nucleotide lesions, derived from endogenous (radical oxygen species, base decay, etc) or exogenous (sunlight, smoke, alcohol, etc.) sources can compromise cellular and organismal health. Cellular responses to DNA damage range from DNA damage responses (DDR) including checkpoints, senescence 1and apoptosis, to nucleotide substitutions and genomic rearrangements [1]. A common inter...
متن کاملStudies of Proliferating Cell Nuclear Antigen Mutant Proteins Defective in Translesion Synthesis and Mismatch Repair
Translesion synthesis (TLS), the process by which DNA polymerases replicate through DNA lesions, is the source of most DNA damage-induced mutations. Sometimes TLS is carried out by classical DNA polymerases that have evolved to synthesize DNA on non-damaged templates. Most of the time, however, TLS is carried out by specialized non-classical DNA polymerases that have evolved to synthesize DNA o...
متن کاملMismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation
Translesion DNA synthesis (TLS) can use specialized DNA polymerases to insert and/or extend nucleotides across lesions, thereby limiting stalled replication fork collapse and the potential for cell death. Recent studies have shown that monoubiquitinated proliferating cell nuclear antigen (PCNA) plays an important role in recruitment of Y-family TLS polymerases to stalled replication forks after...
متن کاملTranslesion synthesis in mammalian cells.
DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five polymerases used in TLS in human cells have different substrate specificities, enabling them to deal with many different types of damaged base...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2015
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2015.1063288